Quick Answer: What Is The Therapeutic Level Of Theophylline?

When should theophylline levels be taken?

Answer: If the sustained release theophylline is given twice a day, then a good time to measure a level is 4 hours after the morning dose.

If the sustained release theophylline is given only once a day, then the blood should be drawn 8-12 hours after the dose..

What are the common side effects of theophylline?

Nausea/vomiting, stomach/abdominal pain, headache, trouble sleeping, diarrhea, irritability, restlessness, nervousness, shaking, or increased urination may occur.

What does theophylline mean?

: a feebly basic bitter crystalline compound C7H8N4O2 present in tea leaves that is isomeric with theobromine and is used in medicine especially as a bronchodilator.

Is there a substitute for theophylline?

Abstract: Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio.

What are the physicochemical properties of theophylline?

Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1. 4.

What happens when you stop taking theophylline?

“If you suddenly stop taking theophylline, your asthma symptoms may return, which could lead to a potentially fatal asthma attack.”

What are the signs and symptoms of theophylline toxicity?

Mechanism of toxicityNervousness.Insomnia.Central respiratory stimulation.Nausea.Vomiting.Tremors.Hyperesthesia.Focal and generalized seizures that progress to status epilepticus in 25%More items…•

How does theophylline cause tachycardia?

Theophylline is a methylxanthine that causes: competitive antagonism of adenosine (e.g. seizures, tachycardia) altered intracellular calcium transport. inhibition of phosphodiesterase leading to an increase in intracellular cAMP concentrations (e.g. tachycardia, metabolic effects, catecholamine release)

What medications can increase the risk of theophylline toxicity?

Causes of chronic theophylline toxicity include the following: Drug interactions (eg, ethanol [ETOH], cimetidine, oral contraceptives, allopurinol, macrolide antibiotics, quinolone antibiotics) Liver disease. Congestive heart failure.

What can increase theophylline levels?

Administration of allopurinol, oral contraceptives, cimetidine, erythromycin, quinolone antibiotics, fluvoxamine, zileuton, and zafirlukast has been shown to increase theophylline levels.

What is the use of theophylline?

Theophylline is used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.

Can I take theophylline and predniSONE together?

Using theophylline together with predniSONE may cause hypokalemia (low blood potassium) and increased theophylline levels. Contact your doctor if you experience weakness, listlessness, confusion, tingling of the extremities, or feelings of heaviness in the legs.

Does theophylline lower blood pressure?

Both theophylline and enprofylline lowered forearm arterial resistance without an increase in CI, LVEF, or cardiac inotropy, although enprofylline tended to cause a lower blood pressure and higher HR than did theophylline.

Is theophylline short or long acting?

Theophylline is available as a pill or as an intravenous (through the vein) drug. It is long-acting and prevents asthma attacks. Theophylline may be used to treat difficult-to-control or severe asthma and must be taken daily.

Is theophylline discontinued?

Reason for the Shortage Major has discontinued theophylline extended-release tablets. Teva has had theophylline extended-release tablets temporarily unavailable for several years. Theophylline 24-hour extended-release presentations are available from Mylan, Rhodes, and Endo Pharmaceuticals.

Is theophylline a stimulant?

Theophylline is a drug derived from methylxanthine (a purine derivative) and has smooth muscle relaxant, bronchial dilation, diuretic, cardiac and central nervous system (CNS) stimulant activities.

What is the classification of theophylline?

Theophylline belongs to a class of drugs called methylxanthines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Theophylline works by opening the airways in your lungs.

Is theophylline still prescribed?

Theophylline is still one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, because it is inexpensive and widely available.

Does coffee interact with theophylline?

theophylline caffeine Avoid drinks or foods that contain caffeine, such as coffee, tea, cola, and chocolate. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

Does coffee contain methylxanthine?

Linked to three of the most consumed beverages (coffee, tea, and cacao) are the most popular methylxanthines: caffeine, theophylline, and theobromine (Table 1). Caffeine is the most abundant methylxanthine in coffee, its level being smaller in chocolate than in coffee.

What foods contain theophylline?

Theophylline is found in black tea and to a lesser extent in green coffee, cocoa cotyledon and dried mate.

What is the use of Etofylline and theophylline?

Etofylline+Theophylline is used in the treatment and prevention of asthma and chronic obstructive pulmonary disease. Etofylline + Theophylline is a combination of two bronchodilators: Etofylline and Theophylline. They work by relaxing the muscles in the airways and widen the airways. This makes breathing easier.

Does green tea contain theophylline?

Black tea, green tea, and oolong tea are all made from the same plant but are prepared using different processing methods. Green tea extract contains polyphenols. … Other significant parts of tea include caffeine, theobromine, and theophylline. The polyphenols of green tea are strong antioxidants.

What is the therapeutic range of theophylline?

The therapeutic concentration for theophylline, when used as a bronchodilator to treat asthma, is generally considered to be 5–15 mcg/mL (28-83 micromol/L) for adults, 5–10 mcg/mL (28–55 micromol/L) for children and neonates. Levels greater than 20 mcg/mL (111 micromol/L) are considered toxic.

What is the antidote for theophylline?

Multidose activated charcoal (MDAC) enhances elimination of theophylline. It is important to control nausea and vomiting in order to perform MDAC treatment.

Is theophylline used for COPD?

Theophylline has been used as a bronchodilator in the treatment of COPD for over 70 years, but has lost popularity as better tolerated and more effective bronchodilators have been introduced.

Why is theophylline not used?

With that said, theophylline may cause a worsening of certain medical conditions and may need to be avoided if you have: Cardiac arrhythmia (irregular heartbeat) Epilepsy or other seizure disorders.